Prison: Day 140

Peepelz! Howyadoin’ this fine morning?

I hope all is well in your corner of the corona-stricken planet and you’re not going bat-shit krayzee in lockydowny. Me? Oh, I’m good. Struggling on, ya know?

With the small-talk outta the way let me show you what you get when you’re not a customer of a mega software corporation but member of a nice Linux community:

endeavoursail
Community member akej74 from Sweden made this wallpaper. Nice, eh?

The proud ship Endeavour sails on to new adventures. And proudly carries the Endeavour logo not in her sails but as her sails. And now we remember Endeavour was Captain Cook’s ship, wasn’t she? And a NASA space shuttle thingie, named after Cook’s boat n stuff. Any way this spirit of discovery and adventure was the inspiration for Endeavour’s developers. And that’s also why we common users get so many exploration and sailing themed wallpapers. 🙂

e-os

Oh boy, it’s wenzday already and no word from the panelbeaters yet. 😐 I sincerely hope they are still busy with the preparations and haven’t already started putting paint on Oubaas. Because first they must put a hi-top on and righten the chassis n stuff. All those things they promised in the beginning and went very timid and avoid talking about now. :/

Boyz, you betta don’t displease the great white huntress! Her wrath will be terrible!

Anyhoo, this is a corona diary, is it not? Better news, any signs of a solution?

newdeathnewinfections
Gauteng/Jo’burg shows again what a shithole it really is.
joburgwall
Shithole city: Johannesburg, Gauteng/RSA

While the Russians report they have a vaccine and will start rolling it out, South Africans are more or less helplessly watching at the rising bodycount. But I gotta say, that the discipline is quite good, from all I see. Everybody’s wearing their masks or at least pulled their turtlenecks up high or wearing a scarf over mouth and nose. Didn’t expect that from the most careless people on the planet. Respect!

rapidtestsa
At least they have their own test kit now.

Chief Executive Officer of SAHPRA, Boitumelo Semete-Makokotlela said in a communication to stakeholders last month the tests, made by Zheijiang Orient Gene Biotech, meet the target product profile under Section 21 authorisation. 

SEE ALSO MONOCLONAL ANTIBODIES COULD BE THE BRIDGE TO A COVID-19 VACCINE

Direct Retail Goods CEO, Graeme Pienaar, said the arrival of the antibody test kits signals an additional tool in the country’s war with coronavirus. 

“With 750 000 units on order, we have commenced the process to secure further stock of these test kits, able to relieve the snowballing backlog of diagnostic Covid-19 tests. The factory’s manufacturing capacity is 2 million kits per day so this announcement may be the additional support that our frontline needs,” he said. 

Semete-Makokotlela said only SAHPRA licence holders who are authorised to manufacture or distribute the test kits are eligible to receive Section 21 authorisation.

 “The tests will be limited for use under the national testing protocol only and is recommended to supplement nucleic acid testing for the diagnosis of suspected Covid-19, to identify recent or remote past sars-CoV-2 infections, targeted cohort surveillance, community screening, specifically for serosurveys or hot spot tracing, population-level epidemiologic studies and surveillance programmes, identification of convalescent plasma donors, and as part of scientific research studies,” she said. 

About the Russians: It was clear that their alleged success was met with much mistrust and jealousy in the west. Media and politics going full-on vitriol. Why? Because the Russians did the clever thing and had federally employed scentists developing the vaccine, put a lot of money and resources in, and didn’t leave the job to the free market.

Because, believe it or not: Saving the human population of this planet is not an economical task but a global emergency! All thoughts about saving cost and creating profit and stealing other nations’ masks should’ve been been put aside long ago, ffs!

russiawho
Not sold? WHO the fuk cares?

DURBAN – Russia’s announcement that it is preparing to start a mass vaccination campaign against Covid-19, this October has not been received well by the World Health Organization (WHO).

The vaccine, which is jointly developed by the Gamaleya National Research Centre for Epidemiology and Microbiology and the Main Military Clinical Burdenko Hospital is listed as being in Phase 1 by the WHO, only six vaccines have progressed as far as wider Phase 3 levels of testing.

Speaking during a UN press briefing, WHO spokesperson Christian Lindmeier told reporters at the United Nations in Geneva said any vaccine or medicine for this purpose should be, of course, going through all the various trials and tests before being licenced for roll-out.

“Sometimes individual researchers claim they have found something, which is of course, as such, great news. But between finding or having a clue of maybe having a vaccine that works, and having gone through all the stages, is a big difference,” said Lindmeier.

According to Russian Minister of Health Mikhail Murashko, the vaccination would be free of charge, and doctors and teachers would be the first to receive it.

“The results of the check-up clearly demonstrate an unmistakable immune response attained through the vaccination. No side effects or issues with the body of the volunteers were found”, the ministry said, according to Sputnik News.

Lindmeier also stated that there are general guidelines, regulations, and rules on how to deal with the safe development of vaccines.

“We have to be always careful when any such measures or highlights or reports come out.These should definitely be followed to make sure that we know what the vaccine or the treatment is working for and against who it can help and of course, also if it has any negative side effects or whether maybe the side effects are bigger than that they actually benefit from it,” he said.

Meanwhile, Russia reported 5,159 new cases of the coronavirus on Tuesday, pushing its national tally to 861,423, the fourth largest in the world.

For LIVE updates on the Coronavirus pandemic, follow us on Twitter:@sacoronamonitor

comp-1_224
No reason to relax anything yet.
russiastats
Steadily declining numbers in Russia: Good but no reaon to let down the guard.
russialaunchvaccine
Good people!

DURBAN – Russia is all set to launch the world’s first Covid-19 vaccine on Wednesday, August 12. According to the Russian health ministry, the Gamaleya vaccine will be first given to doctors and teachers after which there will be a mass vaccination campaign in October. 

However, Russia has not published any findings from its vaccine trials; a great concern for health experts and the World Health Organisation (WHO). The health body has also stepped in and urged the country to follow the established guidelines to produce a ‘safe and effective vaccine’.

Addressing speculations about the safety and efficacy of the vaccine, Alexander Gintsburg, director of the Gamaleya National Research Centre maintained that the Coronavirus particles in the vaccine cannot harm the body as they cannot multiply.

According to Sputnik News Agency, Gintsburg said, “The particles and objects that can reproduce their own kind are the ones that are considered alive. The particles in question cannot multiply.

The country currently has another Covid-19 vaccine candidate being developed by the Vektor State Research Center of Virology and Biotechnology. Scientists from this research centre say they have found that the coronavirus has a major weakness. In a recent study published on Sputnik News report, the scientists found room-temperature water can apparently kill 90 percent of the coronavirus particles in 24 hours. After 72 hours, some 99.9% of the virus’ particles were found to die.

Meanwhile, Philippine President Rodrigo Duterte, has reportedly accepted Russia’s offer of its experimental coronavirus vaccine. According to a report from Bloomberg, Duterte has volunteered to take the first shot as a gesture of trust and gratitude as Moscow geared up to launch the world’s first Covid-19 vaccine.

“When the vaccine arrives, I will have myself injected in public. Experiment on me first, that’s fine with me,” Duterte was quoted as saying in a briefing Monday night.

Russia’s getting serious with the pandemic:

russiavaccine
Despeate times, deperate measures.

Putin claimed that one of his own daughters has already received a dose of the vaccine, according to reports from Moscow—though he didn’t note which daughter. Russian officials pledged to vaccinate millions within the month, starting with healthcare workers and teachers.

Little is known about Sputnik V, which was developed by researchers at the Gamaleya Institute in Moscow. There is no public data on the vaccine, let alone any published, peer-reviewed scientific studies. Public registration of two small clinical trials notes that Sputnik V uses a viral-vector-based design, but they suggest that it has only been tested in a small number of people. The trials, which began less than two months ago, each enrolled 38 healthy volunteers and have an estimated study completion date of August 15.

The World Health Organization, which tracks international COVID-19 vaccine development efforts, lists Sputnik V as being only in the first of three main clinical trial phases. Generally, Phase I clinical trials for vaccines are small—typically only involving dozens of people—and only assess the safety of the candidate. Phase II trials may involve hundreds of people and look further at safety, dosing, and the immune responses that the vaccine triggers, which may hint at the vaccine’s possible efficacy. Then there is the Phase III trial, which often involves tens of thousands of people and looks at whether the vaccine protects against infection and disease.

It appears that Russia has skipped Phase III—and possibly has not finished Phase II yet.

In a meeting Tuesday, Putin reportedly said that “of course, what counts most is for us to be able to ensure the unconditional safety of the use of this vaccine and its efficiency in the future. I hope that this will be accomplished.”

Dubious design

There may already be reason to doubt the efficacy of Sputnik V. The vaccine is a viral vector-based vaccine. That is, it uses two harmless adenoviruses to deliver parts of the pandemic coronavirus, SARS-CoV-2, to the immune system. This is a common design, but it’s one that has a notable pitfall.

Adenoviruses in humans tend to cause mild infections and common colds. For vaccine delivery, they’re usually engineered so they can’t replicate, making them even more harmless. Russian researchers further tinkered with the adenovirus so that it carries the genetic coding for SARS-CoV-2’s spike protein.
The aptly named spike protein is a barb-like structure that juts out from the viral particle and is critical for infection. The spike protein grabs ahold of a receptor on human cells called ACE2 (angiotensin-converting enzyme 2), which allows the virus to get into the cell, take over, and churn out more viral particles. By delivering the spike protein in the adenovirus, researchers are hoping it trains antibodies and defensive immune cells to seek and destroy SARS-CoV-2 by recognizing the spike proteins.Several other high-profile COVID-19 vaccine candidates use this basic strategy—but there’s a catch. Sputnik uses adenoviruses that commonly infect humans. In people who have already been infected with these common viruses, the vaccine may not prompt a strong immune response against the spike protein if immune cells recognize the adenovirus packaging and respond to it instead.

Crazy Russians

This appeared to be the case for a Chinese vaccine candidate developed in part by biotechnology company CanSino. The company’s human adenovirus-based vaccine prompted weaker immune responses to SARS-CoV-2 in people with existing adenovirus immune responses. And in some populations, up to 80 percent of people have had exposure to the human adenovirus the researchers used in the vaccine. Nevertheless, China is pushing ahead with the vaccine, which is now moving to Phase III trials and is already approved for use by the Chinese military.

Another high-profile vaccine developed by the University of Oxford and the international pharmaceutical company AstraZeneca also uses an adenovirus-based delivery. But they dodged the problem of adenovirus immunity by using an adenovirus that primarily infects chimpanzees. The vaccine candidate, which is largely considered more promising by experts, is already in Phase III clinical trials.As for Sputnik V, Phase III trials are going to start soon, according to Kirill Dmitriev, head of the Russian Direct Investment Fund, which financially backed the vaccine’s development. Dmitriev, who spoke with a Moscow-based Washington Post reporter, also said that data from Phase I and Phase II trials will be published later this month—as the vaccine is being distributed to citizens.

He defended the country’s decision to distribute the vaccine before critical clinical trials, saying, “It’s not some crazy Russians using some crazy not proven stuff. Adenovirus existed with humans for thousands of years, and we made a bet on this proven platform because we understand that it takes very little time to develop, given the challenges.”

Last month, officials in the US, UK, and Canada accused hackers linked to Russian intelligence services of trying to steal information about candidate COVID-19 vaccines from academic researchers and pharmaceutical companies. It is “completely unacceptable that the Russian intelligence services are targeting those working to combat the coronavirus pandemic,” Dominic Raab, UK foreign secretary, said at the time. A spokesperson for Putin denied the allegations.

Huh? “It is “completely unacceptable that the Russian intelligence services are” … trying to save human lifes? Can those Anglo-American-European shitheads not stop their antihumane antiganda at least for the time being and join the more reasonable nations in the united fight against Covid-19?

Okeeeeeee… quite enuff concerning news for now isn’t it? I mean it’s only 5:22 a.m. and I’ve already ruined the mood for the day. Asshole me. 😦

Anyhoo, you and yours stay safe/save (I’m never sure about that), stay home if at all possible, wash your hands, eat your veggies, sanitize, avoid contact to other humans. If you love your loved ones – don’t fukn slobber on them! 😮

Cya laterz peepz

xoxo

… and now let’s have fun with Russians:

 

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